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Changes of Rat Serum α-Fetoprotein Levels in Acute Liver Injuries Induced by Hepatotoxins

Bulletin of the Faculty of Agriculture, Yamaguchi University Volume 36 Page 21-30
published_at 1998
Title
各種肝臓毒による急性肝障害時のラット血清中α-フェトプロティン値の動態
Changes of Rat Serum α-Fetoprotein Levels in Acute Liver Injuries Induced by Hepatotoxins
Creators Shibata Hiroshi
Creators Itano Eiko
Creators Yamanaka Hidenori
Source Identifiers
Changes of serum α-fetoprotein (AFP), transaminase (GOT,GPT) and bilrubin levels after a single administration of carbon tetrachloride, galactosamine, α-naphthylisothiocyanate or ethionine were studied in rats 4-5 weeks old. In liver-injured rats with or without necrosis of hepatocells, the serum AFP level increased in propotion to the administered dose of hepatotoxins. Both of increase and recovery in serum AFP level following these hepatotoxins treatment were observed at the same time with those in serum transaminase and bilirubin levels. These observations suggested that the increased production of AFP in these hepatotoxin-treated rats was closely associated with the hepatocellular injury and was not activated in process of the liver cell regeneration.
Subjects
農学 ( Other)
Languages jpn
Resource Type departmental bulletin paper
Publishers 山口大学農学部
Date Issued 1998
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1715
[NCID]AN00244250
Schools 農学部