Effects of Synthetic Peptide, Leu-Leu-Lys-Asp-Leu, on the Growth Hormone Induced Lipolysis

合成ペプチド，Leu-Leu-Lys-Asp-Leuの成長ホルモンによる脂肪動員作用に対する効果

Effects of Synthetic Peptide, Leu-Leu-Lys-Asp-Leu, on the Growth Hormone Induced Lipolysis

Creators Ide Akio

Creators Soeda Mitsuo

Creators Yamasaki Nobuyuki

Creators Masuno Hiroshi

Creators Okuda Hiromichi

In order to explain the mechanism of the lipolysis induced by the growth hormone, several Lys-Asp derivatives have been synthesized and examined the lipolytic activity to the epididymal adipose tissue of rats. Lys-Asp derivatives having either alph-or epsilon-amino group at the N-terminal and carboxyl groups at the C-terminal were concerned to the lipolytic action. This activity was emphasized by allowance of appropriate hydrophobicity. A peptide suited to such conditions was conceived to be Leu-Leu-Lys-Asp-Leu whose sequence was found in the amino acid sequence of boving growth hormone. Therefore, it was suggested that peptide might have the lipolytic activity. Then a peptide, Leu-Leu-Lys-Asp-Leu, was synthesized by the stepwise method and

[ISSN]0513-1715

[NCID]AN00244250