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Clinico-statistical study of the cases of cleft lip and/or palate in the past 10 years at our department

山口医学 Volume 66 Issue 3 Page 169-174
published_at 2017-08-01
B030066000303.pdf
[fulltext] 1.2 MB
Title
当科における過去10年間の口唇・口蓋裂一次症例の臨床統計的検討
Clinico-statistical study of the cases of cleft lip and/or palate in the past 10 years at our department
Creators Shiraishi Mami
Creators Mishima Katsuaki
Creators Umeda Hirotsugu
Creators Ueyama Yoshiya
Source Identifiers
Creator Keywords
口唇裂 口蓋裂 臨床統計
本邦において,口唇・口蓋裂は出生約600人に1人の割合で発生する発生頻度の高い体表奇形の一つである.2006年1月から2016年6月までの間に山口大学医学部附属病院歯科口腔外科を受診した,口唇・口蓋裂一次症例(未手術症例)72名を対象とし,臨床統計的検討を行った.裂型別では口唇口蓋裂が28例(38.9%),口蓋裂(粘膜下口蓋裂を含む)が27例(37.5%),口唇裂が17例(23.6%)であった.男児34名,女児38名と性差はなかったが,口唇口蓋裂は男児に,口蓋裂は女児に多い傾向があり,口唇裂はほぼ同数であった.披裂側の検討では,両側裂(15.6%)より片側裂(84.4%)が多く,左側(48.9%)に多かった.合併異常の頻度は16.7%で,特に口蓋裂患者に多くみられた.合併異常の内訳は先天性心疾患が最も多く,次いで耳介,四肢奇形であった.染色体異常を8.3%に認め,特に粘膜下口蓋裂に高い傾向があり,また過去の報告より高い傾向であった.家族内発生率は12.5%で,特に口唇裂を合併した患者に高い傾向がみられた.
Cleft lip and cleft palate are some of the most frequent body surface malformations, occurring in about 1 per 600 births in Japan. Herein, we report a clinico-statistical investigation of 72 patients with cleft lip and / or cleft palate in the past 10 years. The patients were primary(non-surgical)cases at the Department of Oral and Maxillofacial Surgery, Yamaguchi University Graduate School of Medicine.The numbers of patients with cleft lip and cleft palate, cleft palate, submucous cleft palate and cleft lip were 28(38.9%),18(25.0%),9(12.5%)and 17(23.6%),respectively. There were a total of 34 male and 38 female patients. Associated complicating malformations and / or disorders were observed in 12 patients(16.7%)and were more frequently detected in the patients with cleft palate.Chromosomal disorders were found in 6 patients(8.3%),with a high percentage for those with submucous cleft palate. Incidence of familial recurrence was 12.5%, with a high percentage for patients with cleft lip.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 2017-08-01
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 大学院医学系研究科