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Fatty Acids Compositions in Epidermal Cyst and Psoriatic

山口医学 Volume 46 Issue 2 Page 85-93
published_at 1997-04
Title
低リノール酸血症乾癬患者組織中脂肪酸組成に関する研究
Fatty Acids Compositions in Epidermal Cyst and Psoriatic
Creators Nagai Ko
Source Identifiers
Creator Keywords
低リノール酸血症 乾癬鱗屑 粉瘤 組織中脂肪酸
Fatty acid obtained from epidermal cyst and psoriatic scale were studied in order to elucidate error of lipid metabolisms concerning keratinization. Lipids from contents of an epidermal cyst and scale obtained from a patient with psoriasis vulgaris, were analyzed quantitatively and compared with those of epidermal cyst, clavushorny layer from normal volunteers. The thin-layer chromatography was used for detection of cholesterol ester, triglyceride, free fatty acids, cholesterol and phospholipids. Fatty acid components of some lipids were converted to methyl esters and confirmed by gas-liquid chromatography (GLC). The fatty acid compositions of scale and an epidermal cyst of psoriatic patient revealed smaller amount of C18:0 and greater amount of C18:1 and C18:2 than those of clavus horny layer and an epidermal cyst of normal volunteers. The increase ofC18:2in psoriatic scale suggests that much linoleic acid might be transported into corneocytes from serum. The increase of C18:1 and C18:2 may contribute to membrane fluidity, leading to suppression of terminal differentiation.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1997-04
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部