Clinical significance ^<123>I-IMP single photon emission computed tomography in detecting regional cerebral blood flow

^<123>I-IMP single photon emission computed tomography (SPECT) の臨床的有用性の検討 : Xe-CT 脳血流測定との対比を中心として

Clinical significance ^<123>I-IMP single photon emission computed tomography in detecting regional cerebral blood flow

Creators Shiroyama Yujiro

Creators Nakayama Hisato

Creators Takasago Teiichi

Creators Tamashita Tetsuo

Creators Abiko Seisho

Creators Ito Haruhide

Creators Nishihara Sadamitsu

Creators Utsumi Hiromoto

Creators Yamada Norimasa

In order to estimate the N-isopropy- (I-123) p-Iodoamphetamine (^<123>I-IMP) single-photon-emission-computed tomography (SPECT) and cold Xenon CT, Cerebral blood flow (CBF) by means of both methods were measured almost simultaneously in 13 patients. The patients (10 males and 3 female) showed an age distribution from 33 to 69 years (mean＝57.4 years). Eleven patients had cerebral infarction and the other two patients had cerebral hemorrhage. All oatients have been at the choronic stage. ^<123>I-IMP was utilized for SPECT using a rotating gamma-camera system. The uptakes of ^<123>I-IMP were counted for 2030 min and again 3-4 hours after the injection. The CBF by Xe-CT was mesured by means of Xe gas inhalation method. The results were as follows : 1) In the correlation of L/R ratio between ^<123>I-IMP-SPECT and Xe-CT, the ratin of ^<123>I-IMP uptake count correlated to the CBF ratio in Xe-CT. 2) The diffuse low CBF areas may be well visualized by SPECT rather than by CT-scan. 3) CBF image of ^<123>I-IMP-SPECT could be useful to evaluate cerebro-vescular diseases. Moreover, it may provide some insights into the pathophysiology of cerebral remote effect and vaibility.

[ISSN]0513-1731

[NCID]AN00243156