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Hyperbaric oxygen, perfluorochemical and artificial hypotension as an adjunct to acute reperfusion of middle cerecral arterial occlusion in cats

山口医学 Volume 37 Issue 2 Page 113-120
published_at 1988-04
Title
脳動脈閉塞に対する急性期血行再開のための補助治療の実験的研究 : 人為的低血圧、人工血液、高気圧酸素の効果
Hyperbaric oxygen, perfluorochemical and artificial hypotension as an adjunct to acute reperfusion of middle cerecral arterial occlusion in cats
Creators Yamashita Tetsuo
Source Identifiers
The effect of hyperbaric oxygen (HBO), perfluorochemical (PFC) and hypotensive reperfusion on postischemic cerebral edema was studied. The middle cerebral artery in cats was transorbitally occluded for 3 hrs and reperfused for 3 hrs. The cats whose CBF decreased to lower than 10ml/100g/min by the occlusion were used. The HBO (2atm, pure oxygen) was started one hour after the occlusion and continued for one hour. The mean arterial blood pressure was lowered artificially about 50mmHg from the previous value using adenosine triphosphate and dipyridamole just before and during the reperfusion. The value of CBF 3 hours after reperfusion was 8.2±11.0ml in the control group(n=10), 18.1±12.2ml in the hypotension group(n=6), 25.4±14.2ml in the PFC group(PFC with hypotension, n=5), and 27.5±9.0ml in the HBO group(HBO with hypotension, n=6). The ICP increased to 90.0±22.6mmHg in the control group and in the hypotension group to 37.7±10.1mmHg, in the PFC group to 43.2±17.1mmHg and in the HBO group to 29.8±20.9mmHg. The water content of the affected hemisphere was 79.7±0.5% in the control group, 79.1±0.5% in the hypotension group and 78.3±0.5% in the HBO group. These results suggest that the hypotensive reperfusion decreases vascular bed and reduces the strain on the vasoparalytic vascular wall thus improving the vasogenic edema. The PFC and the HBO help the metabolism of the vascular wall to improve during ischemia and maintain the strength of the vessel wall against intravascular pressure and reduce the edema. In conclusion, HBO, Pfc, and hypotensive reperfusion are useful as adjunts to actue cerebral revascularization.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1988-04
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部