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Effect of Several Organic Solvents Inhalation on Systemic Blood Pressure

山口医学 Volume 32 Issue 2 Page 211-216
published_at 1983-04
Title
各種有機溶剤吸入による血圧変動
Effect of Several Organic Solvents Inhalation on Systemic Blood Pressure
Creators Kobayashi Haruo
Creators Hobara Tatsuya
Creators Kawamoto Toshihiro
Creators Higashihara Eiji
Creators Hashizume Akira
Creators Shimazu Wataru
Creators Sakai Tsunemi
Source Identifiers
In order to investigate the effects of some organic solvents inhalation on systemic blood pressure, 1, 1, 1-trichloroethane (1, 1, 1-TCE), trichloroethylene, tetrachloroethylene, toluene and m-xylene were separately inhaled during a period of one to three minutes in anesthetized dogs under positive pressure ventilation. The results were as follows. 1) A fall in blood pressure was induced by each solvent inhalation. The threshold concentration of trichloroethylene, tetrachloroethylene, toluene, m-xyleneand 1, 1, 1-TCE inhalation to produce the fall in blood pressure was about 0.1%, 0.1%, 0.2%, 0.45% and 0.4 t o0.5%, respectively. These results indicated that the fall in blood pressure was induced following each solvent inhalation, however, each threshold concentration to produce the fall in blood pressure was different. 2) Moreover, it was observed that blood pressure markedly fell with the increase in concentration which was more than threshold level of each solvent. 3) Degree of the fall in blood pressure following trichloroethylene, tetrachloroethylene, toluene, m-xylene and 1, 1, 1-TCE inhalation in concentration of about 1.0%, respectively, was about 20 to 30 mmHg, 30mmHg, 10 to 15mmHg, 10 to 12mmHg, 10 to 20mmHg, respectively. 4) The mentioned results suggested that shock due to high concentration inhalation of organic solvents may be related to a cause of acute death in industrial fields.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1983-04
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部