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High Pressure as a Mechanical Stress and Mitogen-Activated Protein Kinase Activation in Glomerular Diseases

The bulletin of the Yamaguchi Medical School Volume 46 Issue 3-4 Page 71-77
published_at 1999-12
A020046000302.pdf
[fulltext] 700 KB
Title
High Pressure as a Mechanical Stress and Mitogen-Activated Protein Kinase Activation in Glomerular Diseases
Creators Kawata Yasunobu
Source Identifiers
Creator Keywords
mechanical stress MAP kinase mesangial cell
Progressive renal diseases lead to prolonged glomerular hypertension, which acts as a mechanical stress to mesangial cells and induced the proliferation of mesangial cells. In mesangial cell proliferation, various growth factors and mitogemic stimuli are known to induce the activation of mitogen-activated protein kinase (MAPK), whish serves as an important regulator of transcriptional activity with cell proliferation. Here I review the relationship of glomerular hypertension as a mechanical stress and MAPK activation, which induces glomerular sclerosis through proliferation in mesangial cells.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1999-12
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部