Troglitazone-Induced Liver Injury Diagnosed by a Laparoscopic Examination in Its Asymptomatic Stage
The bulletin of the Yamaguchi Medical School Volume 46 Issue 1-2
Page 41-44
published_at 1999-06
Title
Troglitazone-Induced Liver Injury Diagnosed by a Laparoscopic Examination in Its Asymptomatic Stage
Creators
Inoue Yasushi
Creators
Yamada Tetsuya
Creators
Katsuki Kensaku
Creators
Kato Akira
Creators
Kodama Takahiro
Creators
Kamei Toshiaki
Source Identifiers
Creator Keywords
troglitazone
diabetes mellitus
liver injury
A 56-year-old diabetic woman had been taking glibenclamide (10 mg daily) plus voglibose (0.6 mg daily) for recent 4 years without a successful response. Three months after troglitazone (400 mg daily) was started in addition to glibenclamide, liver dysfunction was found by chance. She demonstrated no symptoms, histological examination, however, revealed a substantial hepatocelluar necrosis mainly in the peri-central vein areas, which was consistent with an idiosyncratic drug reaction. Since troglitazoneinduced liver dtsfunction was strongly suggested, administaration of troglitazone was terminated and abnormal values of liver-chemistry returned to normal in two months.
Languages
eng
Resource Type
departmental bulletin paper
Publishers
Yamaguchi University Graduate School of Medicine
Date Issued
1999-06
File Version
Version of Record
Access Rights
open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools
医学部