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Measurement of Cerebral Cortical Blood Flow by Laser-Doppler Flowmetry in Rat Forebrain Ischemia

The bulletin of the Yamaguchi Medical School Volume 38 Issue 3-4 Page 61-66
published_at 1991-12
A020038000304.pdf
[fulltext] 459 KB
Title
Measurement of Cerebral Cortical Blood Flow by Laser-Doppler Flowmetry in Rat Forebrain Ischemia
Creators Yamashita Katsuhiro
Creators Eguchi Yuuki
Creators Shiroyama Yujiro
Creators Yamashita Tetsuo
Creators Ito Haruhide
Source Identifiers
Creator Keywords
Laser-Doppler flowmetry Cerebral blood flow Forebrain ischemia rat
Laser-Doppler flowmetry is a new method allowing convenient and continuous measurement of blood flow. The aim of our sutdy was to evaluate the accuracy of Laser-Doppler flowmetry for measurement of blood flow in the central nervous system, compared with the established hydrogen clearance method, especially under ischemic conditions. Ten male Wistar rats were subjected to 60 min of forebrain ischemia, induced by occlusion of the bilateral common carotid arteries and unilateral vertebral artery with systemic hypotension. Under these conditions, the cerebral cortical blood flow was measured, by both methods simultaneously, three times in each animal. The cerebral blood flows measured by the hydrogen clearance method and Laser-Doppler flowmetry showed linear relationship (r=0.89, p<0.01). Laser-Doppler flowmetry facilitates accurate measurement of relative cerebral cortical blood flow under ischemic conditions.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1991-12
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部