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Radioprotective Action of SH Compounds Ⅲ. Effects of Aminoethyliosothjuronium Br. HBr, Cysteamine and 2-Mercaptopropionylglycine Against Mitotic Delay Induced By X-Rays.

The bulletin of the Yamaguchi Medical School Volume 20 Issue 1-2 Page 45-51
published_at 1973-06
A020020000105.pdf
[fulltext] 372 KB
Title
Radioprotective Action of SH Compounds Ⅲ. Effects of Aminoethyliosothjuronium Br. HBr, Cysteamine and 2-Mercaptopropionylglycine Against Mitotic Delay Induced By X-Rays.
Creators Kawasaki Shoji
Source Identifiers
Protection by SH compounds (MPG, cysteamine and AET) against the mitotic delay induced by X-irradiation in Ehrlich ascites tumor cells was studied. With exposure to 200 rads, the mitotic delay time and its recovery of the group treated with SH compounds (0.5 mg MPG, 2 mg cysteamine and 3 mg AET) were similar to those of non-treated group up to 12 hours after irradiation, but at 12 hours and rater the mitotic index of the groups treated with SH compounds was at a much higher level. The recovery rate from the mitotic inhibition became faster by increasing the concentration of the SH compounds (4 mg cysteamine or 6 mg AET) injected. Similar effects of SH compound were observable in the case of 400-rad irradiation. Increasing the concentration of the SH compound (4 mg cysteamine or 6 mg AET) treated, the recovery of mitosis was accelerated remarkably. From these data, it is suggested that the SH compound has a differential protective effect on mitotic delay the cell cycle.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1973-06
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部