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Significance of Serum Leucine Aminopeptidase Isozyme in Hepatobiliary Diseases

The bulletin of the Yamaguchi Medical School Volume 13 Issue 2 Page 89-93
published_at 1966-06
A020013000205.pdf
[fulltext] 272 KB
Title
Significance of Serum Leucine Aminopeptidase Isozyme in Hepatobiliary Diseases
Creators Wajima Takeshi
Source Identifiers
The serum LAP zymograms of 140 cases of hepatobiliary diseases were examined. Normal cases show only one activity bands, but 48 % of cases of hepatobiliary diseases showed 2 or 3 activity bands. The appearance of this pathological LAP isozyme is not necessarily parallel to increases in serum LAP activity or bilirubin concentration. A certain degree of hepatic parenchymal disturbances is necessary for pathological isozyme to appear. However, when there is no bile duct obstruction, no matter how severe parenchymal disturbances may be, no pathological isozyme appears. This pathological isozyme is almost specific to obstruction of the bile duct. When an icteric patient shows 2 pathological serum isozymes, there is a very strong possibility of this cse being probable cholelithiasis of malignant bile duct obstruction. Case of bile duct obstruction with no increase of serum GPT show only one pathological LAP isozyme and those which have increased serum GPT show 2pathological isozymes.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1966-06
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部