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Immunological response of dogs to Dirofilaria immitis infection

The Japanese journal of veterinary science Volume 43 Issue 6 Page 909-914
published_at 1981
2008010288.pdf
[fulltext] 561 KB
Title
犬糸状虫寄生犬における免疫応答について
Immunological response of dogs to Dirofilaria immitis infection
Creators Hayasaki Mineo
Creators Nakagaki Kazuhide
Creators Kobayashi Shigeo
Creators Ohishi Isamu
The immunological responses of dogs infected with Dirofilaria immitis were studied by macrophage migration inhibition (MI) test (indirect method), indirect hemagglutination (IHA) test and passive cutaneous anaphylaxis reaction. Both 13 non-infected dogs and 20 naturally infected dogs were negative for MI test, when examined with antigens prepared from adult worms and intrauterine microfilariae. Three dogs experimentally infected with D. immitis (98 to 121 infective larvae) and 2 non-infected controls were monitored for the kinetics of immunological responses during the course of infection. In infected dogs, both IHA and reaginic antibody productions were demonstrated throughout prepatent and patent periods of the infection. It seems likely that the marked production of these antibodies was associated with the timing of fourth larval molt and the occurence of microfilaremia. Nevertheless, the MI tests were negative for these dogs throughout the prepatent period of the infection.
Languages jpn
Resource Type journal article
Publishers 日本獣医学会
Date Issued 1981
File Version Version of Record
Access Rights open access
Relations
[ISSN]0021-5295
[NCID]AN00191788
[isVersionOf] [URI]http://www.jstage.jst.go.jp/browse/jvms/-char/ja
[isVersionOf] Dirofilaria immitis infection and dirofilariosis : an animal model of human filariosis [URI]http://www.lib.yamaguchi-u.ac.jp/yunoca/handle/2010010511
Schools 農学部