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Influence of immune treatments against Dirofilaria immitis infection in dogs

Japanese journal of veterinary science Volume 51 Issue 3 Page 540-546
published_at 1989
2008010282.pdf
[fulltext] 516 KB
Title
Influence of immune treatments against Dirofilaria immitis infection in dogs
Creators Hayasaki Mineo
Creators Ohishi Isamu
Creator Keywords
Dirofilaria immitis immune treatment Metastrongylus apri
Mongrel dogs were inoculated with two kinds of antigenic substances. The first was a phosphate buffered saline extract of whole Dirofilaria immitis mixed with aluminum hydroxide gel (group 1), and the second was an orally administered live Metastrongylus apri infective larvae (L_3) (group 2). Both groups were then infected with D. immitis L_3. Indirect hemagglutination (IHA) tests showed that the antibody was produced by these inoculations before the infection was introduced, even in dogs inoculated with M. apri. This suggests a cross-reactivity between D. immitis and M. apri. The initial passive cutaneous anaphylaxis (PCA) antibody production was markedly delayed by about 70 days in group 2 compared with the production in the infected control dogs (group 3). The appearance of microfilaremia was also delayed by about one month in group 2 compared with that in the above control group. All dogs were sacrificed after the termination of the observation and worms recovered from the right ventricle and pulmonary arteries were counted and measured. The results indicated that immunization resulting from the homologous worm-somatic antigen might accelerate the growth of the infected larvae, whereas immunization resulting from the heterologous worm antigen, but cross-reactive to D. immitis, might disadvantageously affect the growth.
Languages eng
Resource Type journal article
Publishers 日本獣医学会
Date Issued 1989
File Version Version of Record
Access Rights open access
Relations
[ISSN]0021-5295
[NCID]AA10521639
[isVersionOf] [URI]http://www.jstage.jst.go.jp/browse/jvms/-char/ja
[isVersionOf] Dirofilaria immitis infection and dirofilariosis : an animal model of human filariosis [URI]http://www.lib.yamaguchi-u.ac.jp/yunoca/handle/2010010511
Schools 農学部